Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells
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چکیده
منابع مشابه
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1 Progesterone receptors (PR) are critical mediators of mammary gland development and 2 contribute to breast cancer progression. Progestin-induced rapid activation of 3 cytoplasmic protein kinases leads to selective regulation of growth-promoting genes by 4 phospho-PR species. Herein, we show that phosphorylation of PR Ser81 is ck25 dependent and progestin-regulated in intact cells, but also oc...
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BACKGROUND/AIMS Breast cancer resistance protein (BCRP) plays a crucial role in multidrug resistance (MDR). Previous studies have shown that steroid hormones, like progesterone (PROG), regulate BCRP expression. The presence of a progesterone response element (PRE) in the BCRP promoter, suggests that PROG may regulate transcription of BCRP. METHODS To investigate the role of PROG in the regula...
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The human progesterone receptor (PR) is expressed as two isoforms, PRA and PRB, which differ in the N-terminal region and exhibit different activities in vitro, with PRA demonstrating dominant negative inhibitory effects on the activity of PRB and other nuclear receptors. PRA and PRB are expressed in target tissues at comparable levels although cells expressing a predominance of one isoform can...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2018
ISSN: 1945-7170
DOI: 10.1210/en.2018-00559